Dimethylamine → HCID 178483050, compound

HRID 1195432Notes

Reaction equation

HRID 1195432 reaction equation
[NH:1]1[C:10](=O)C2NC=NC=2N[C:2]1=O.O=P(Cl)(Cl)Cl.[Cl:17][C:18]1[N:26]=[C:25]2[C:21]([N:22]=[CH:23][NH:24]2)=[C:20](Cl)[N:19]=1.CNC>>[Cl:17][C:18]1[N:26]=[C:25]2[C:21]([N:22]=[CH:23][NH:24]2)=[C:20]([N:1]([CH3:10])[CH3:2])[N:19]=1

Participants

5

Reactant 4

HCID 674DimethylamineHCID 1188XanthineHCID 24813Phosphorus oxychlorideHCID 1784188752,6-dichloro-1H-purine

Product 1

HCID 178483050HCID 178483050, compound

Procedure

Xanthine (2,6-dihydroxy-9H-purine) is converted by reaction with phosphorus oxytrichloride in accordance with G. B. Elion and G. H. Hitchings, J. Am. Chem. Soc. 78, 3508 (1956) into the 2,6-dichloro-9H-purine and the latter is reacted with N,N-dimethylamine in accordance with J. A. Montgomery and L. B. Holum, J. Am. Chem. Soc. 80, 404 (1958) to form 2-chloro-6-(N,N-dimethylamino)-9H-purine.

Sources & evidence

ORD record
ord-ebea918d104246ce8bee12f764ffc000
Source dataset
uspto-grants-1992_05
Patent number
US05110818

Reaction notes

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