Dimethylamine → HCID 53887279, compound

HRID 1195440Notes

Reaction equation

HRID 1195440 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])=[C:4]([NH:20][CH3:21])[N:3]=1.[CH3:22][NH:23][CH3:24]>>[F:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([F:18])[C:12]=1[CH2:11][N:8]1[CH:7]=[N:6][C:5]2[C:9]1=[N:10][C:2]([N:23]([CH3:24])[CH3:22])=[N:3][C:4]=2[NH:20][CH3:21]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 53953767HCID 53953767, compound

Product 1

HCID 53887279HCID 53887279, compound

Procedure

In a manner analogous to that described in Example 2 it is possible, by reacting 2-chloro-9-(2,6-difluorobenzyl)-6-(N-methylamino)-9H-purine (Example 17) with N,N-dimethylamine, to obtain the 9-(2,6-difluorobenzyl)-2-(N,N-dimethylamino)-6-(N-methylamino)-9H-purine, which has a melting range of from 196° to 199° (methanol), the reaction mixture being heated at 140° for 24 hours.

Sources & evidence

ORD record
ord-f19db34e4f0d4939a78681d710e674be
Source dataset
uspto-grants-1992_05
Patent number
US05110818

Reaction notes

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