Trichloroacetic Acid → HCID 13746606, compound

HRID 1195607Notes

Reaction equation

HRID 1195607 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][NH:6][C:7](=[O:11])[N:8]([CH3:10])[CH3:9].[Cl:16][C:17]([Cl:22])([Cl:21])[C:18]([OH:20])=[O:19]>C(OCC)C>[Cl:16][C:17]([Cl:22])([Cl:21])[C:18]([OH:20])=[O:19].[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([Cl:15])[CH:14]=1)[O:5][NH:6][C:7](=[O:11])[N:8]([CH3:10])[CH3:9]

Participants

4

Reactant 2

HCID 6421Trichloroacetic AcidHCID 13746375HCID 13746375, compound

Product 1

HCID 13746606HCID 13746606, compoundYield 94.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

2.25 g (9 mmole) of 3-(3,5-dichlorophenoxy)-1,1-dimethyl urea was dissolved in 300 ml of diethyl ether, and then 50 ml of a diethyl ether solution containing 1.47 g (9 mmole) of trichloroacetic acid was added. The mixture was stirred at a temperature of from 25° to 30° C. for 24 hours. Diethyl ether was distilled off and ml of hexane was added. The crystals thereby precipitated were collected by filtration and dried, whereby 3.52 g of the desired product was obtained as colorless acicular crystals (yield: 95%).

Workup

  1. additionwas added
  2. distillationDiethyl ether was distilled off
  3. additionwas added
  4. customThe crystals thereby precipitated
  5. filtrationwere collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-1f461b41e7da4250af1487a204de1b81
Source dataset
uspto-grants-1992_05
Patent number
US05112385

Reaction notes

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