Methyl bromoacetate → HCID 15166966, compound

HRID 1195650Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:16])=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[N:9]2)=[CH:4][CH:3]=1.Br[CH2:18][C:19]([O:21][CH3:22])=[O:20]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([O:16][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[N:9]2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 178498504HCID 178498504, compound

Product 1

HCID 15166966HCID 15166966, compound

Procedure

The purified methyl 7-chloro-4-hydroxy-2-quinoline-carboxylate was alkylated with methyl bromoacetate as described in example 2 to produce methyl 7-chloro-4-methoxycarbonylmethyloxy-2-quinolinecarboxylate as a white solid having a melting point of 153.5°-154.5° C.

Sources & evidence

ORD record: ord-84079d95ce55423d8c5be765cb1a2c60
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05112821

Reaction notes

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