Benzhydrylpiperazine → HCID 15228134, compound

HRID 1195694Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:12])=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[C:13]1([CH:19]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:26]1([CH:19]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:20]2[CH2:21][CH2:22][N:23]([CH2:4][CH:5]([OH:12])[CH2:6][O:12][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[C:11]4[C:6]=3[CH:7]=[CH:8][CH:9]=[N:10]4)[CH2:24][CH2:25]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

Reactant 2

HCID 70048Benzhydrylpiperazine

HCID 1360706908-chloroquinolin-5-ol

Product 1

HCID 15228134HCID 15228134, compound

Procedure

Following the same procedure as in Example 23-(c), reaction and treatment were carried out using 0.64 g of 8-chloro-5-hydroxyquinoline and 1.48 g of 4-chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine synthesized in Example 23-(b), in order to obtain 0.68 g of 5-[3-(4-diphenylmethylpiperazine-1-yl)-2-hydroxypropoxy]-8-chloroquinoline.

Workup

customas in Example 23-(c), reaction and treatment

Sources & evidence

ORD record: ord-a7e3b3c43e8a4f818d2d00cbc6d2e37d
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05112817

Reaction notes

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