Benzhydrylpiperazine → HCID 20079161, compound

HRID 1195706Notes

Reaction equation

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[OH:14])[N:4]=1.[C:17]1([CH:23]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:16][C:2]([F:1])([F:15])[C:3]1[CH:12]=[C:11]([CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:14][CH2:8][CH:9]([OH:14])[CH2:10][N:27]2[CH2:26][CH2:25][N:24]([CH:23]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:29][CH2:28]2)[N:4]=1

Participants

Reactant 2

HCID 70048Benzhydrylpiperazine

HCID 136070691HCID 136070691, compound

Product 1

HCID 20079161HCID 20079161, compound

Procedure

Following the same procedures as in Example 1-(a) and (b), reaction and treatment were carried out using 2-trifluoromethyl-4-methyl-5-hydroxyquinoline prepared in Example 54 and N-diphenylmethylpiperazine in order to obtain the desired compound.

Sources & evidence

ORD record: ord-4423705fc451473b9fa9f897c2234812
Source dataset: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05112817

Reaction notes

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