Chloroacetone → HCID 54442238, compound

HRID 1195740Notes

Reaction equation

HRID 1195740 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.Cl[CH2:11][C:12](=O)[CH3:13].C([O-])(O)=O.[Na+]>C(O)C.O>[Cl:9][C:5]1[CH:6]=[C:7]([Cl:8])[C:2]2[N:3]([CH:11]=[C:12]([CH3:13])[N:1]=2)[CH:4]=1

Participants

6

Reactant 3

HCID 6571ChloroacetoneHCID 778863,5-Dichloro-3-pyridylamineHCID 516892Sodium Bicarbonate

Product 1

HCID 54442238HCID 54442238, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 30 g 2-amino-3,5-dichloropyridine and 39 ml chloroacetone dissolved in 260 ml ethanol is heated under reflux for 64 hours. The volatile components are stripped off in vacuum and the residue suspended in 200 ml water. This is brought to pH 7-8 by means of saturated aqueous NaHCO3 -solution. A filtrate is obtained under suction and dried to constant weight in vacuo and recrystallized from cyclohexane. 17.8 g of the title compound of m.p. 156°-158° C. is obtained.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 64 hours
  3. customA filtrate is obtained under suction
  4. customdried to constant weight in vacuo
  5. customrecrystallized from cyclohexane

Sources & evidence

ORD record
ord-6676d71dfd724355bba898c68c879b55
Source dataset
uspto-grants-1992_05
Patent number
US05112834

Reaction notes

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