Hydrochloric Acid → HCID 15157751, compound

HRID 1195746Notes

Reaction equation

HRID 1195746 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([C:19]([OH:21])=[O:20])[C:12]=1C1C=CC=CC=1)[NH:9][CH2:8][CH2:7][CH:6]2[C:22]([OH:24])=[O:23])#N.[OH-:25].[Na+].Cl.[OH2:28]>>[C:3]1([CH:8]2[CH2:7][CH:6]([C:22]([OH:24])=[O:23])[C:5]3[C:10](=[C:11]([C:19]([OH:21])=[O:20])[CH:12]=[C:3]([C:1]([OH:28])=[O:25])[CH:4]=3)[NH:9]2)[CH:4]=[CH:5][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 14798Sodium HydroxideHCID 54074885HCID 54074885, compound

Product 1

HCID 15157751HCID 15157751, compoundYield 76.4%

Procedure

A solution of the compound obtained in example 17 b) (5.6 g) and sodium hydroxide (5 g) in water (20 ml) was refluxed for 10 hours. After cooling, water (200 ml) was added and the mixture was adjusted to pH 2 by the addition of concentrated hydrochloric acid. The resulting precipitate from the mixture was collected by filtration, washed with water, dried to give the title compound (3.05 g, 76.4%) which was recrystallized from DMF-ethanol to white crystals, mp 300° C.

Workup

  1. temperatureAfter cooling
  2. filtrationThe resulting precipitate from the mixture was collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-26683e7c63844880a22274327514897f
Source dataset
uspto-grants-1992_05
Patent number
US05112836

Reaction notes

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