Methyl iodide → HCID 54217133, compound

HRID 1195754Notes

Reaction equation

HRID 1195754 reaction equation
[NH:1]1[C:7]2=[C:8]3[C:13](=[N:14][C:15]4[CH2:16][CH2:17][CH2:18][CH:5]([C:6]=42)[O:4][CH2:3][C:2]1=[O:19])[CH:12]=[CH:11][CH:10]=[CH:9]3.[CH3:20]C(C)([O-])C.[K+].CI>O1CCCC1>[CH3:20][N:1]1[C:7]2=[C:8]3[C:13](=[N:14][C:15]4[CH2:16][CH2:17][CH2:18][CH:5]([C:6]=42)[O:4][CH2:3][C:2]1=[O:19])[CH:12]=[CH:11][CH:10]=[CH:9]3

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 23665647Potassium tert-butoxideHCID 54455005HCID 54455005, compound

Product 1

HCID 54217133HCID 54217133, compoundYield 46.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1,3,4a,5,6,7-hexahydro-2H-quino[4,3,2-ef][1,4]-benzoxazepin-2-one (4.09 g) in tetrahydrofuran (100 ml) was added potassium t-butoxide (2.17 g) followed by methyl iodide (1.25 ml). The reaction mixture was stirred for 2 hrs at ambient temperature and then concentrated. The residue was stirred in water/ethyl ether, the precipitate was collected and dried to give 2.0 g (46%) of 1,3,4a,5,6,7-hexahydro-1-methyl-2H-quino[4,3,2-ef][1,4]benzoxazepin-2-one.

Workup

  1. concentrationconcentrated
  2. stirringThe residue was stirred in water/ethyl ether
  3. customthe precipitate was collected
  4. customdried

Sources & evidence

ORD record
ord-29ef79e61658411ba5d4d80772dd16ce
Source dataset
uspto-grants-1992_05
Patent number
US05112829

Reaction notes

Loading…