Ammonium Chloride → HCID 9795016, compound

HRID 1195763Notes

Reaction equation

HRID 1195763 reaction equation
[NH2:1][C:2]1[C:3]2[C:8]([N:9]=[C:10]3[C:15]=1[CH2:14][CH2:13][CH2:12][CH2:11]3)=[CH:7][CH:6]=[CH:5][C:4]=2[O:16][CH2:17][C:18]([O:20]CC)=O.CC(C)([O-])C.[K+].[Cl-].[NH4+]>O1CCCC1>[NH:1]1[C:2]2=[C:15]3[C:10](=[N:9][C:8]4=[CH:7][CH:6]=[CH:5][C:4](=[C:3]24)[O:16][CH2:17][C:18]1=[O:20])[CH2:11][CH2:12][CH2:13][CH2:14]3

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 20068607Ethyl[(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetateHCID 23665647Potassium tert-butoxide

Product 1

HCID 9795016HCID 9795016, compoundYield 82.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl [(9-amino-1,2,3,4-tetrahydroacridin-8-yl)oxy]acetate (14.50 g) was dissolved in dry tetrahydrofuran (350 ml) and potassium t-butoxide (6.0 g) was added. After stirring for 1 hr, 100 ml saturated ammonium chloride solution (100 ml) was added, and stirring was continued for 30 min. The reaction mixture was evaporated under reduced pressure. The solid was collected and washed with water to give 10.15 g (82.65%) of product, mp 201°-202° C.

Workup

  1. stirringstirring
  2. waitwas continued for 30 min
  3. customThe reaction mixture was evaporated under reduced pressure
  4. customThe solid was collected
  5. washwashed with water

Sources & evidence

ORD record
ord-7961b27f4492495085b6c348f4987345
Source dataset
uspto-grants-1992_05
Patent number
US05112829

Reaction notes

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