Potassium Hydroxide → HCID 14857377, compound

HRID 1195811Notes

Reaction equation

HRID 1195811 reaction equation
[CH3:1][C:2]1([CH3:29])[CH:11](O)[CH:10]([C:13]2[C:14](=[O:26])[N:15]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:16]=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:27]#[N:28])[CH:8]=2)[O:3]1.[OH-:30].[K+]>C(O)(C)(C)C>[CH3:1][C:2]1([CH3:29])[CH:11]=[C:10]([C:13]2[C:14](=[O:26])[N:15]([CH2:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:16]=[CH:17][CH:18]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:27](=[O:30])[NH2:28])[CH:8]=2)[O:3]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 14857308HCID 14857308, compound

Product 1

HCID 14857377HCID 14857377, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A mixture of 5.8 g of 2,2-dimethyl-4-(1-benzyl-1,2-dihydro-2-oxo-3-pyridyl)-6-cyano-3-chromanol, 11.6 g of KOH and 90 ml of tert.-butanol is boiled for 50 min., cooled and poured onto ice. Customary working up gives 2,2-dimethyl-4-(1-benzyl-1,2-dihydro-2-oxo-3-pyridyl)-6carbamoyl-3-chromene, m.p. 199°-202°.

Workup

  1. temperaturecooled
  2. additionpoured onto ice

Sources & evidence

ORD record
ord-552ff9e1d5f640d09a830f2c9b3b37a7
Source dataset
uspto-grants-1992_05
Patent number
US05112839

Reaction notes

Loading…