Isobutyryl chloride → HCID 15027357, compound

HRID 1195864Notes

Reaction equation

HRID 1195864 reaction equation
[OH:1][NH:2][CH2:3][C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[CH:5]=1.[C:17](Cl)(=[O:21])[CH:18]([CH3:20])[CH3:19]>>[CH:5]1[C:6]2[CH2:7][C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[CH:16][C:4]=1[CH2:3][N:2]([OH:1])[C:17](=[O:21])[CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 62325Isobutyryl chlorideHCID 15027353HCID 15027353, compound

Product 1

HCID 15027357HCID 15027357, compound

Procedure

Using the method in Example 4, N-hydroxy-9H-fluorene-2-methanamine is reacted with isobutyryl chloride to give N-(9H-fluoren-2-ylmethyl)-N-hydroxy-2-methyl-propanamide as white crystalline solid. Yield 3.5 g (62%); mp 163°-166° C.

Sources & evidence

ORD record
ord-3b930617132f42a6a379ac01e3d8b603
Source dataset
uspto-grants-1992_05
Patent number
US05112846

Reaction notes

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