反应详情

To a stirred solution of 3-carbomethoxy-2,5-dimethylfuran (2.5 g, 16.2 mmol) in methylene chloride (distilled from CaH) at -20° C., under N2, was added 2.5 eq of DIBAL (1M in CH2Cl2). After 1 h, the dry ice/acetonitrile bath was removed and 60 mL of 10% HCl was added dropwise. The organic layer was separated, dried over MgSO4, and evaporated. The residue was chromatographed (silica gel, 60% ether/hexane) to yield 1.3 g of 2,5-dimethyl-3- hydroxymethylfuran.

1. customthe dry ice/acetonitrile bath was removed
2. addition60 mL of 10% HCl was added dropwise
3. customThe organic layer was separated
4. dry with materialdried over MgSO4
5. customevaporated
6. customThe residue was chromatographed (silica gel, 60% ether/hexane)