HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Xylyl bromide → 2-(2-Methylbenzyloxy)-acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Xylyl bromide | HCID 6992 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | alpha-Hydroxyacetophenone | HCID 68490 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2-Methylbenzyloxy)-acetophenone | HCID 53889895 | 59% |
Reaction Steps
102 g (0.75 mol) of 2-hydroxyacetophenone and 102 g (0.75 mol) of potassium carbonate in 500 ml of absolute ethanol are initially taken. 139 g (0.75 mol) of 2-methylbenzyl bromide are added dropwise and the mixture is refluxed for 10 h. The mixture is cooled and filtered under suction, after which the filtrate is evaporated down. The crude product is recrystallized from diethyl ether. 106 g (59%) of product are obtained as crystals (mp.=53°-55° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05112862 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-260ec844d7294184a2ce3d4db9931734 |
| Source note | uspto-grants-1992_05 |