Pivaloyl chloride → HCID 54344073, compound

HRID 1195940Notes

Reaction equation

HRID 1195940 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:15])[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[OH:8].[C:22](Cl)(=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24]>O1CCCC1>[C:22]([O:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:15])[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[C:7]=1[OH:8])(=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24]

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 53849680HCID 53849680, compound

Product 1

HCID 54344073HCID 54344073, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.0 g of the product obtained in Example 8 was dissolved in 5 ml of tetrahydrofuran, 4.7 ml of pivaloyl chloride was added and the mixture was refluxed for 16 h. The solvent was evaporated in vacuo and the residue was purified in a silicagel column by using toluene-acetic acid-dioxane (18:1:1) mixture as an eluent. The product was crystallized from ether, m.p. 148°-150° C.

Workup

  1. temperaturethe mixture was refluxed for 16 h
  2. customThe solvent was evaporated in vacuo
  3. customthe residue was purified in a silicagel column
  4. customThe product was crystallized from ether, m.p. 148°-150° C.

Sources & evidence

ORD record
ord-3fba6d736a5249b584e0fde97a2b7465
Source dataset
uspto-grants-1992_05
Patent number
US05112861

Reaction notes

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