Cyanoacetamide → HCID 53944143, compound

HRID 1195980Notes

Reaction equation

HRID 1195980 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=O.[C:14]([CH2:16][C:17]([NH2:19])=[O:18])#[N:15].C(O)(=O)C.N1CCCCC1>C(O)C>[C:14]([C:16](=[CH:5][C:4]1[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]([OH:10])=[C:2]([OH:1])[CH:3]=1)[C:17]([NH2:19])=[O:18])#[N:15]

Participants

5

Reactant 3

HCID 7898CyanoacetamideHCID 57489573,4-Dihydroxy-5-nitrobenzaldehydeHCID 9793820Piperidine, acetate

Product 1

HCID 53944143HCID 53944143, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution containing 1.3 g of 3,4-dihydroxy-5-nitro-benzaldehyde, 0.73 g of cyanoacetamide and catalytic amount of piperidine acetate in 40 ml of dry ethanol was refluxed over night. The solvent was evaporated in vacuo and the residue was recrystallized water-DMF. Yield 0.84 g (48%), m.p. 296-298° C.

Workup

  1. temperaturewas refluxed over night
  2. customThe solvent was evaporated in vacuo
  3. customthe residue was recrystallized water-DMF

Sources & evidence

ORD record
ord-b1e6d373bdfa42b285caba74b7df2039
Source dataset
uspto-grants-1992_05
Patent number
US05112861

Reaction notes

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