Methyl Acrylate → HCID 14838421, compound

HRID 1196014Notes

Reaction equation

HRID 1196014 reaction equation
[CH3:1][O:2][C:3](=[O:6])[CH:4]=[CH2:5].[NH2:7][CH2:8][CH:9]1[O:14][C:13]2[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=2[O:11][CH2:10]1>CO>[CH3:1][O:2][C:3]([CH2:4][CH2:5][N:7]([CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:6])[CH2:8][CH:9]1[O:14][C:13]2[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=2[O:11][CH2:10]1)=[O:6]

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 150532-Aminomethyl-1,4-benzodioxane

Product 1

HCID 14838421HCID 14838421, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7.57 g (88 mmol) of acrylic acid methyl ester are added to a solution of 6.61 g (40 mmol) of 2-aminomethylbenzo-1,4-dioxan [J. Augustin et al., J. Med. Chem. 8, 446 (1965)] in 80 ml of methanol and the whole is stirred for 16 hours at 50°. After cooling, the reaction mixture is concentrated by evaporation in vacuo. 12.82 g (95%) of N,N-bis(2-methoxycarbonylethyl)-N-(benzo-1,4-dioxan-2-ylmethyl)-amine are obtained in the form of a reddish oil.

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture is concentrated by evaporation in vacuo

Sources & evidence

ORD record
ord-b98aeaff0f9c4cb28134f9938c617d24
Source dataset
uspto-grants-1992_05
Patent number
US05112855

Reaction notes

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