Methyl Acrylate → HCID 14838425, compound

HRID 1196015Notes

Reaction equation

HRID 1196015 reaction equation
[CH3:1][O:2][C:3](=[O:6])[CH:4]=[CH2:5].[NH2:7][CH2:8][CH2:9][CH:10]1[O:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[O:12][CH2:11]1>CO>[CH3:1][O:2][C:3]([CH2:4][CH2:5][N:7]([CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:6])[CH2:8][CH2:9][CH:10]1[O:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[O:12][CH2:11]1)=[O:6]

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 556482-(2,3-Dihydro-1,4-benzodioxin-2-yl)ethanamine

Product 1

HCID 14838425HCID 14838425, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

34.1 g (0.396 mol) of acrylic acid methyl ester are added at room temperature to a solution of 32.25 g (0.18 mol) of 2-(2-aminoethyl)-benzo-1,4-dioxan [J. Augustin et al., J. Med. Chem. 8, 446 (1965)] in 250 ml of methanol. The reaction mixture is stirred for 6 hours at 50° and, after cooling, is concentrated by evaporation in vacuo. 57.9 g (91.5%) of N,N-bis(2-methoxycarbonylethyl)-N-[2-(benzo-1,4-dioxan-2-yl)ethyl]-amine are obtained in the form of a red oil.

Workup

  1. temperatureafter cooling
  2. concentrationis concentrated by evaporation in vacuo

Sources & evidence

ORD record
ord-e87824787f18424a8cdef8c6034dc5a4
Source dataset
uspto-grants-1992_05
Patent number
US05112855

Reaction notes

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