Hydrochloric Acid → L-Serine, methyl ester, hydrochloride (1:1)

Participants

Reaction Steps

The same esterification procedure as in Example 1 was followed with the exception that the L-phenylalanine was replaced with 105.6 g of L-serine and that 105.6 g of methanol and 50.5 g of hydrochloric acid were used. Following cooling to deposit the crystals, which were collected by filtration and then dried to obtain 134.4 g (83.8% yield) of L-serine methyl ester hydrochloride having a purity of 97.0% and containing 0.2% of water and 0.7% of L-serine.

Provenance & Evidence