Hydrochloric Acid → L-Serine, methyl ester, hydrochloride (1:1)

HRID 1196150Notes

Reaction equation

HRID 1196150 reaction equation
N[C@H:2](C(O)=O)CC1C=CC=CC=1.[NH2:13][C@H:14]([C:17]([OH:19])=[O:18])[CH2:15][OH:16].[ClH:20]>CO>[ClH:20].[CH3:2][O:18][C:17](=[O:19])[C@H:14]([CH2:15][OH:16])[NH2:13]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5951L-SerineHCID 6140L-Phenylalanine

Product 1

HCID 2723730L-Serine, methyl ester, hydrochloride (1:1)Yield 83.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The same esterification procedure as in Example 1 was followed with the exception that the L-phenylalanine was replaced with 105.6 g of L-serine and that 105.6 g of methanol and 50.5 g of hydrochloric acid were used. Following cooling to deposit the crystals, which were collected by filtration and then dried to obtain 134.4 g (83.8% yield) of L-serine methyl ester hydrochloride having a purity of 97.0% and containing 0.2% of water and 0.7% of L-serine.

Workup

  1. temperatureFollowing cooling
  2. filtrationwere collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-a5109e9923654a128a9e06660999e2e6
Source dataset
uspto-grants-1992_05
Patent number
US05113009

Reaction notes

Loading…