反应详情

To 2.21 g of Compound 101 obtained by Example 101 was added 50 ml of ethanol and 50 ml of saturated aqueous sodium hydrogencarbonate, and the mixture was heated under reflux for 2 hours. After the reaction was completed, the solvent was evaporated under reduced pressure. Precipitated crystals were washed with water and then recrystallized to afford 1.05 g of the desired compound (Compound 120)

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 hours
3. customthe solvent was evaporated under reduced pressure
4. customPrecipitated crystals
5. washwere washed with water
6. customrecrystallized