HRID1196170

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7943

Dimethyl malonate

C5H8O4

$结构：COC(=O)/C=C(\CCl)OC$

HCID6364655

未命名化合物

HCID10942334

Methanol, sodium salt

CH3NaO

2 次

PRODUCTS

生成物

$结构：COC(=O)/C=C(\CC(C(=O)OC)C(=O)OC)OC$

HCID11436868

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 20 °C

PROCEDURE

实验过程

66 g (0.5 mol) of malonic acid dimethyl ester was placed in 250 ml of N,N'-dimethylformamide. 27.8 g (0.5 mol) of sodium methylate was added at 20° C.; 10 minutes later 41.6 g (0.25 mol) of 4-chloro-3-methoxy-2E-butenoic acid methyl ester was added within 5 minutes. It was stirred for 2 hours at 20° C. Then 10.8 g (0.2 mol) of sodium methylate was added once more. After stirring for 15 hours at 20° C. it was distilled off. After working up according to Example (a) 53.8 g (81 percent) of the title compound, with a purity of 98 percent (GC), was obtained. Data for the title compound was:

WORKUP

后处理

stirringAfter stirring for 15 hours at 20° C. it
distillationwas distilled off
customwas obtained