Morpholine → HCID 54504679, compound

HRID 1196180Notes

Reaction equation

HRID 1196180 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.O[CH2:13][CH:14]1[N:19]([S:20]([CH3:23])(=[O:22])=[O:21])[C:18]2[CH:24]=[CH:25][CH:26]=[CH:27][C:17]=2[O:16][CH2:15]1.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>CN1CCCC1=O>[N:28]1([CH2:13][CH:14]2[N:19]([S:20]([CH3:23])(=[O:22])=[O:21])[C:18]3[CH:24]=[CH:25][CH:26]=[CH:27][C:17]=3[O:16][CH2:15]2)[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 88501948HCID 88501948, compound

Product 1

HCID 54504679HCID 54504679, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

In the same manner, the isomeric 3-hydroxymethyl-4-methanesulfonyl-3,4-dihydro-2H-1,4-benzoxazine p-toluenesulfonate obtained above (40.8 g, 0.10 mole) was reacted with 60 ml of morpholine in 100 ml of N-methylpyrrolidone to give 22.5 g of 3-(4-morpholinylmethyl)-4-methanesulfonyl-3,4-dihydro-2H-1,4-benzoxazine.

Sources & evidence

ORD record
ord-774d5a44fce94b18abac818f21a4e567
Source dataset
uspto-grants-1992_05
Patent number
US05112820

Reaction notes

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