反应详情

To a solution of (3S,4S)-4-(1-chloromethylethenyl)-3-(1-(R)-benzyloxycarbonyloxyethyl)-1-di(p-anisyl)methyl-2-azetidinone (2.24 g) in acetone (25 ml) was added sodium iodide (1.2 g), and the resultant mixture was stirred at room temperature for 5 hours and concentrated in vacuo to make a volume of about 10 ml. The concentrated solution was diluted with benzene (50 ml) and diethyl ether (50 ml), washed successively with 5% sodium bicarbonate and water and dried over anhydrous sodium sulfate. Filtration and concentration of the filtrate in vacuo gave (3S,4S)-4-(1-iodomethylethenyl)-3-(1-(R)-benzyloxycarbonyloxyethyl)-1-di-(p-anisyl)methyl-2-azetidinone.

1. concentrationconcentrated in vacuo
2. additionThe concentrated solution was diluted with benzene (50 ml) and diethyl ether (50 ml)
3. washwashed successively with 5% sodium bicarbonate and water
4. dry with materialdried over anhydrous sodium sulfate
5. filtrationFiltration and concentration of the filtrate in vacuo