HCID 56999954, compound → HCID 57161867, compound

HRID 1196228Notes

Reaction equation

HRID 1196228 reaction equation
[CH3:1][N:2]([C:14]([C:16]1[CH:21]=[C:20]([O:22]CC2C=CC=CC=2)[C:19]([O:30]CC2C=CC=CC=2)=[C:18]([CH2:38][NH:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[N:17]=1)=[O:15])[NH:3]C(OCC1C=CC=CC=1)=O>CN(C)C=O>[CH3:1][N:2]([C:14]([C:16]1[NH:17][C:18]([CH2:38][NH:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])=[C:19]([OH:30])[C:20](=[O:22])[CH:21]=1)=[O:15])[NH2:3]

Participants

3

Reactant 1

HCID 56999954HCID 56999954, compound

Product 1

HCID 57161867HCID 57161867, compoundYield 82.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

To a solution of the compound of Example 36d (1.49 g, 2.37 mmol) in 30 ml dimethylformamide 0.7 g 10% palladium on carbon catalyst were added and a stream of hydrogen was bubbled through the mixture for 1 hour. The catalyst was filtered off and the filtrate evaporated in vacuo. Trituration of the residue with ether yielded 0.61 g of the desired product. M.P. 188°-190° C. (dec.)

Workup

  1. customa stream of hydrogen was bubbled through the mixture for 1 hour
  2. filtrationThe catalyst was filtered off
  3. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-0c6cedcb9ad64c63a29a78ec1af68288
Source dataset
uspto-grants-1992_05
Patent number
US05112968

Reaction notes

Loading…