Hydrochloric Acid → HCID 67915814, compound

Participants

Reaction Steps

(3aRS,7aRS)-2-{[2-(N-tert-Butoxycarbonyl-N-methylamino)phenyl]acetyl}-7,7-diphenylperhydro-4-isoindolone (2.8 g) is treated with a 5.7N solution (30 cc) of hydrochloric acid in dry dioxane at 20° C. for 4 hours. Isopropyl ether (100 cc) is added and the solid is drained, washed with isopropyl ether and dried. (3aRS,7aRS)-2-[(2-methylaminophenyl)acetyl]-7,7-diphenylperhydro-4-isoindolone hydrochloride (2.1 g) is obtained in the form of a white solid.

Provenance & Evidence