Hydrochloric Acid → HCID 67915814, compound

HRID 1196278Notes

Reaction equation

HRID 1196278 reaction equation
C(O[C:6]([N:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][C:17]([N:19]1[CH2:27][CH:26]2[CH:21]([C:22]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:23][CH2:24][C:25]2=[O:28])[CH2:20]1)=[O:18])C)=O)(C)(C)C.[ClH:41].C(OC(C)C)(C)C>O1CCOCC1>[ClH:41].[CH3:6][NH:8][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][C:17]([N:19]1[CH2:27][CH:26]2[CH:21]([C:22]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH2:23][CH2:24][C:25]2=[O:28])[CH2:20]1)=[O:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 67916214HCID 67916214, compound

Product 1

HCID 67915814HCID 67915814, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(3aRS,7aRS)-2-{[2-(N-tert-Butoxycarbonyl-N-methylamino)phenyl]acetyl}-7,7-diphenylperhydro-4-isoindolone (2.8 g) is treated with a 5.7N solution (30 cc) of hydrochloric acid in dry dioxane at 20° C. for 4 hours. Isopropyl ether (100 cc) is added and the solid is drained, washed with isopropyl ether and dried. (3aRS,7aRS)-2-[(2-methylaminophenyl)acetyl]-7,7-diphenylperhydro-4-isoindolone hydrochloride (2.1 g) is obtained in the form of a white solid.

Workup

  1. washwashed with isopropyl ether
  2. customdried

Sources & evidence

ORD record
ord-b311198d652349a2a81ec54917bb09d9
Source dataset
uspto-grants-1992_05
Patent number
US05112988

Reaction notes

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