HRID1196294

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O

HCID11011585

tert-Butyloxycarbonyl-L-alanine-N-hydroxysuccinimide

C12H18N2O6

HCID21866389

未命名化合物

结构：CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1

HCID178451951

未命名化合物

PRODUCTS

生成物

结构：C[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)OCc1ccccc1

HCID178462202

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

The desired compound was prepared from 28.9 g of Boc-Pro-Arg(NO2)-OBzl, 150 ml of 4N HCl-AcOEt, 8 ml of Et3N and 16.3 g of Boc-Ala-OSu in the same manner as in Example 8-(1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f658aa6294e54f24bd7ce9e34c463411
来源数据集: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05112947
来源说明: uspto-grants-1992_05

反应 SMILES

[N:1]1([C:30](OC(C)(C)C)=[O:31])[CH2:29][CH2:28][CH2:27][C@H:2]1[C:3]([NH:5][C@H:6]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:16])[NH:12][N+:13]([O-:15])=[O:14])=[O:4].Cl.CCOC(C)=O.[NH:44]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@H:45](C(ON1C(=O)CCC1=O)=O)[CH3:46]>CCN(CC)CC>[NH:44]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@H:45]([C:30]([N:1]1[CH2:29][CH2:28][CH2:27][C@H:2]1[C:3]([NH:5][C@H:6]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:16])[NH:12][N+:13]([O-:15])=[O:14])=[O:4])=[O:31])[CH3:46]