Boc-Ala-OSu → HCID 178462202, compound

HRID 1196294Notes

Reaction equation

HRID 1196294 reaction equation
[N:1]1([C:30](OC(C)(C)C)=[O:31])[CH2:29][CH2:28][CH2:27][C@H:2]1[C:3]([NH:5][C@H:6]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:16])[NH:12][N+:13]([O-:15])=[O:14])=[O:4].Cl.CCOC(C)=O.[NH:44]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@H:45](C(ON1C(=O)CCC1=O)=O)[CH3:46]>CCN(CC)CC>[NH:44]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@H:45]([C:30]([N:1]1[CH2:29][CH2:28][CH2:27][C@H:2]1[C:3]([NH:5][C@H:6]([C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:16])[NH:12][N+:13]([O-:15])=[O:14])=[O:4])=[O:31])[CH3:46]

Participants

5

Reactant 3

HCID 11011585Boc-Ala-OSuHCID 21866389Hydrogen chloride-ethyl acetateHCID 178451951HCID 178451951, compound

Product 1

HCID 178462202HCID 178462202, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The desired compound was prepared from 28.9 g of Boc-Pro-Arg(NO2)-OBzl, 150 ml of 4N HCl-AcOEt, 8 ml of Et3N and 16.3 g of Boc-Ala-OSu in the same manner as in Example 8-(1).

Sources & evidence

ORD record
ord-f658aa6294e54f24bd7ce9e34c463411
Source dataset
uspto-grants-1992_05
Patent number
US05112947

Reaction notes

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