HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Amino-4,4,4-trifluoro-3-methylbutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4,4,4-Trifluoro-3-methyl-2-butenoic acid | HCID 5708835 | — |
| Solvent | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-Amino-4,4,4-trifluoro-3-methylbutanoic acid | HCID 18179360 | — |
Reaction Steps
A solution of 3-trifluoromethylcrotonic acid (10 g) and liquid ammonia (23 ml) in ammonium hydroxide (27 ml sd=0.88) was heated in a closed steel vessel at 148°-152° C. for 16 hours evaporation of the cooled solution gave 3-amino-3-trifluoromethylbutyric acid (10.2 g), as a viscous colourless oil. ##STR6##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05114461 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-c27264e9d67d466ea1febf67ff0c5466 |
| Source note | uspto-grants-1992_05 |