Ammonia → 3-Amino-4,4,4-trifluoro-3-methylbutanoic acid

HRID 1196420Notes

Reaction equation

HRID 1196420 reaction equation
[F:1][C:2]([F:10])([F:9])/[C:3](/[CH3:8])=[CH:4]\[C:5]([OH:7])=[O:6].[NH3:11]>[OH-].[NH4+]>[NH2:11][C:3]([C:2]([F:10])([F:9])[F:1])([CH3:8])[CH2:4][C:5]([OH:7])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 57088354,4,4-Trifluoro-3-methyl-2-butenoic acid

Product 1

HCID 181793603-Amino-4,4,4-trifluoro-3-methylbutanoic acid

Reagents, catalysts & solvents 1

HCID 14923Ammonium HydroxideSolvent

Procedure

A solution of 3-trifluoromethylcrotonic acid (10 g) and liquid ammonia (23 ml) in ammonium hydroxide (27 ml sd=0.88) was heated in a closed steel vessel at 148°-152° C. for 16 hours evaporation of the cooled solution gave 3-amino-3-trifluoromethylbutyric acid (10.2 g), as a viscous colourless oil. ##STR6##

Workup

  1. customevaporation of the cooled solution

Sources & evidence

ORD record
ord-c27264e9d67d466ea1febf67ff0c5466
Source dataset
uspto-grants-1992_05
Patent number
US05114461

Reaction notes

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