Hydrochloric Acid → HCID 19898458, compound

HRID 1196449Notes

Reaction equation

HRID 1196449 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([NH:13]C(=O)C)=[CH:10][CH:9]=[C:8]2[S:17]([OH:20])(=[O:19])=[O:18].Cl>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[C:11]([NH2:13])=[CH:10][CH:9]=[C:8]2[S:17]([OH:20])(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19898446HCID 19898446, compound

Product 1

HCID 19898458HCID 19898458, compound

Procedure

8-Methoxy-1-acetylaminonaphthalene-4-sulfonic acid is suspended in 20%-strength hydrochloric acid and the suspension is heated under a reflux condenser while stirring at 90°-100° C. After approx 1-11/2 hours, the deacetylation is complete. The mixture is allowed to cool to 20°-25° C., the slightly pink-colored crystals are filtered off by suction, they are washed on the sintered disk filter funnel with water and then dried in a vacuum drying oven at 50°-60° C.

Workup

  1. temperaturethe suspension is heated under a reflux condenser
  2. custom2 hours
  3. temperatureto cool to 20°-25° C.
  4. filtrationthe slightly pink-colored crystals are filtered off by suction, they
  5. washare washed on the sintered disk
  6. filtrationfilter funnel with water
  7. customdried in a vacuum
  8. customdrying oven at 50°-60° C.

Sources & evidence

ORD record
ord-d365cc6bba894a018249436ad934032e
Source dataset
uspto-grants-1992_05
Patent number
US05114816

Reaction notes

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