反应详情

A mixture of 2.0 g of 4-chloro-8-fluoroquinoline and 3.8 g of 2-(2-naphthyl)ethyl amine was heated under nitrogen to 160°-165° C. for one hour. Then 200 mL of a 50:50 mixture of ammonium hydroxide in water was added. The product was extracted from the mixture into CH2Cl2, which was then concentrated to dryness. The residue was recrystallized from pentane/ethyl acetate to give 1.4 g of the title product. Yield 41.2%. M.P. 173°-174° C.

1. temperaturewas heated under nitrogen to 160°-165° C. for one hour
2. additionwas added
3. extractionThe product was extracted from the mixture into CH2Cl2, which
4. concentrationwas then concentrated to dryness
5. customThe residue was recrystallized from pentane/ethyl acetate