Dipropylamine → HCID 19898813, compound

Participants

Reaction Steps

A mixture of 3.5 g (0.013 mole) of 2-phenylpyrazolo[1,5-a]pyrimidine-3-acetic acid and 2.24 g (0.013 mole) of 1,1'-carbonyldiimidazole in 150 ml of anhydrous tetrahydrofuran was stirred for 4 hours at room temperature while nitrogen was bubbled through the mixture. After additional stirring, a solution of 4.19 g (0.041 mole) of di-n-propylamine in 10 ml of anhydrous tetrahydrofuran was added dropwise and the mixture was stirred for about 17 hours under a nitrogen atmosphere. The solvent was evaporated under reduced pressure and the residue (7.3 g) was recrystallized from ethanol-water to give 3.3 g of product (72%), mp 103°-105° C.

Provenance & Evidence