Methylamine → HCID 19898803, compound

Participants

Reaction Steps

A suspension of 3.0 g (0.011 mole) of 5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine-3-acetic acid and 1.73 g (0.011 mole) of 1,1'-carbonyldiimidazole in 120 ml of anhydrous tetrahydrofuran was stirred at room temperature for 4 hours while a stream of nitrogen was bubbled through the mixture. The clear solution which formed was treated with a solution of monomethylamine in tetrahydrofuran (12.8 ml; 0.033 mole; 2.59M) and the mixture stirred at room temperature for 17 hours under nitrogen.

Provenance & Evidence