Methylamine → HCID 19898803, compound

HRID 1196497Notes

Reaction equation

HRID 1196497 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:11]([CH2:12][C:13](O)=[O:14])=[C:4]2[N:3]=1.[C:22](N1C=CN=C1)([N:24]1C=CN=C1)=O.CN>O1CCCC1>[CH3:22][NH:24][C:13](=[O:14])[CH2:12][C:11]1[C:10]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[N:9][N:5]2[C:6]([CH3:8])=[CH:7][C:2]([CH3:1])=[N:3][C:4]=12

Participants

5

Reactant 3

HCID 6329MethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 19898805HCID 19898805, compound

Product 1

HCID 19898803HCID 19898803, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A suspension of 3.0 g (0.011 mole) of 5,7-dimethyl-2-phenylpyrazolo[1,5-a]pyrimidine-3-acetic acid and 1.73 g (0.011 mole) of 1,1'-carbonyldiimidazole in 120 ml of anhydrous tetrahydrofuran was stirred at room temperature for 4 hours while a stream of nitrogen was bubbled through the mixture. The clear solution which formed was treated with a solution of monomethylamine in tetrahydrofuran (12.8 ml; 0.033 mole; 2.59M) and the mixture stirred at room temperature for 17 hours under nitrogen.

Workup

  1. customwas bubbled through the mixture
  2. customThe clear solution which formed
  3. stirringthe mixture stirred at room temperature for 17 hours under nitrogen

Sources & evidence

ORD record
ord-cb1e1393aab744ec9ba764ff1451d38f
Source dataset
uspto-grants-1992_05
Patent number
US05114944

Reaction notes

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