反应详情

温度

150 °C

A mixture of the product of stage (iv) (0.887 g) and pyrrolidine (2.2 ml) was heated at 150° C. in an autoclave for 2 h, allowed to cool to room temperature and evaporated to dryness giving an oil (1.27 g). This was purified by flash chromatography eluting with chloroformmethanol (9:1), to give an oil which crystallised on standing to give the title compound as a solid (841 mg), m.p. 72.5°-74.5°.

1. temperatureto cool to room temperature
2. customevaporated to dryness