反应详情

A solution of the product of stage (iv) (50 mg) in ethanol (2 ml) was hydrogenated at 70 psi and 70° over 5% rhodium on carbon (35 mg) for 14 h. The mixture was filtered and the filtrate was evaporated in vacuo. The residue (0.1 g) was purified by flash chromatography eluting with dichloromethane/methanol/ammonia 200:10:2 to give the title compound as an oil (0.018 g). T.l.c. (Silica/dichloromethane/methanol/ammonia 75:10:2) Rf 0.6.

1. filtrationThe mixture was filtered
2. customthe filtrate was evaporated in vacuo
3. customThe residue (0.1 g) was purified by flash chromatography
4. washeluting with dichloromethane/methanol/ammonia 200:10:2