Water → HCID 19899000, compound

HRID 1196655Notes

Reaction equation

HRID 1196655 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]3[CH2:13][CH2:14][CH2:15][CH:16]([C:18]([O:20]C)=[O:19])[CH2:17][C:11]3(N3CCCC3)[O:10][N:9]=2)=[CH:4][CH:3]=1.O>S(=O)(=O)(O)O.C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]3[CH2:13][CH2:14][CH2:15][CH:16]([C:18]([OH:20])=[O:19])[CH2:17][C:11]=3[O:10][N:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 962WaterHCID 19899079HCID 19899079, compound

Product 1

HCID 19899000HCID 19899000, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 1118Sulfuric AcidSolvent

Procedure

5 g of methyl 3-(4-chlorophenyl)-3a,5,6,7,8,8a-hexahydro-8a-pyrrolidino-4H-cyclohept[d]isoxazole-7-carboxylate in 5 ml of concentrated sulfuric acid, 5 ml of acetic acid and ml of water were heated at 120° C. for 5 hours. The separated product was filtered off, washed with water and dried in vacuo to give 3.1 of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 215°-217° C.

Workup

  1. filtrationThe separated product was filtered off
  2. washwashed with water
  3. customdried in vacuo

Sources & evidence

ORD record
ord-f1e63d96e6e641b8840a55292dd0018c
Source dataset
uspto-grants-1992_05
Patent number
US05114960

Reaction notes

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