Water → HCID 19899000, compound

Participants

Reaction Steps

5 g of methyl 3-(4-chlorophenyl)-3a,5,6,7,8,8a-hexahydro-8a-pyrrolidino-4H-cyclohept[d]isoxazole-7-carboxylate in 5 ml of concentrated sulfuric acid, 5 ml of acetic acid and ml of water were heated at 120° C. for 5 hours. The separated product was filtered off, washed with water and dried in vacuo to give 3.1 of 3-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 215°-217° C.

Provenance & Evidence