Potassium Hydroxide → HCID 19899076, compound

HRID 1196656Notes

Reaction equation

HRID 1196656 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH2:13][CH2:14][CH2:15][C:16]([CH3:22])([C:18]([O:20]C)=[O:19])[CH2:17][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH-].[K+]>O.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]3[CH2:13][CH2:14][CH2:15][C:16]([CH3:22])([C:18]([OH:20])=[O:19])[CH2:17][C:11]=3[O:10][N:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 19899033HCID 19899033, compound

Product 1

HCID 19899076HCID 19899076, compoundYield 47.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2 g of methyl 3-(4-chlorophenyl)-7-methyl-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylate were treated with 0.5 g of potassium hydroxide in 2 ml of water and 20 ml of methanol at 20° C. for 16 hours. After working-up as described in Example 5 and crystallization from glacial acetic acid, there was obtained 0.9 g of 3-(4-chlorophenyl)-7-methyl-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 232°-235° C.

Workup

  1. customas described in Example 5 and crystallization from glacial acetic acid

Sources & evidence

ORD record
ord-89dc80aedd8a4920911d29134bd54810
Source dataset
uspto-grants-1992_05
Patent number
US05114960

Reaction notes

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