Potassium Hydroxide → HCID 19899076, compound

Participants

Reaction Steps

2 g of methyl 3-(4-chlorophenyl)-7-methyl-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylate were treated with 0.5 g of potassium hydroxide in 2 ml of water and 20 ml of methanol at 20° C. for 16 hours. After working-up as described in Example 5 and crystallization from glacial acetic acid, there was obtained 0.9 g of 3-(4-chlorophenyl)-7-methyl-5,6,7,8-tetrahydro-4H-cyclohept[d]isoxazole-7-carboxylic acid of melting point 232°-235° C.

Provenance & Evidence