Methanesulfonyl chloride → HCID 131717378, compound

HRID 1196713Notes

Reaction equation

HRID 1196713 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].O[CH2:7][CH2:8][S:9]([C:12]1[CH:13]=[C:14]([C@H:26]2C[CH2:29][C@H:28]([C:31]3[CH:36]=[C:35]([O:37][CH3:38])[C:34]([O:39][CH3:40])=[C:33]([O:41][CH3:42])[CH:32]=3)[O:27]2)C=[C:16]([O:22][CH2:23][CH2:24][CH3:25])[C:17]=1OCCC)(=[O:11])=[O:10].[CH3:43]CCCCC.[C:49]([O:52][CH2:53][CH3:54])(=O)[CH3:50]>ClCCl.N1C=CC=CC=1>[CH3:1][S:2]([CH2:7][CH2:8][S:9]([C:12]1[CH:17]=[C:16]([O:22][CH2:23][CH2:24][CH3:25])[C:49]([O:52][CH2:53][CH2:54][CH3:43])=[CH:50][C:13]=1[CH:14]1[CH2:29][CH:28]([C:31]2[CH:32]=[C:33]([O:41][CH3:42])[C:34]([O:39][CH3:40])=[C:35]([O:37][CH3:38])[CH:36]=2)[O:27][CH2:26]1)(=[O:11])=[O:10])(=[O:4])=[O:3]

Participants

6

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 15078318HCID 15078318, compoundHCID 21226206Ethyl acetate hexane

Product 1

HCID 131717378HCID 131717378, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

Methanesulfonyl chloride (0.097 mL, 1.25 mmol) was added to a solution of trans-2-[3-(2-hydroxyethylsulfonyl)-4,5-di-n-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (338 mg, 0.63 mmol) in dichloromethane (3 mL) and pyridine (1.3 mL). The reaction mixture was stirred at room temperature for 2 h, and worked-up as usual to give a syrup, Rf 0.52 (hexane-ethyl acetate; 1:2 v/v). This material was used directly in the next experiment without further purification.

Workup

  1. customThis material was used directly in the next experiment without further purification

Sources & evidence

ORD record
ord-7d60563fc02e49918cbf64423b021ab9
Source dataset
uspto-grants-1992_05
Patent number
US05114961

Reaction notes

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