Methanesulfonyl chloride → HCID 131717378, compound

Participants

Reaction Steps

Methanesulfonyl chloride (0.097 mL, 1.25 mmol) was added to a solution of trans-2-[3-(2-hydroxyethylsulfonyl)-4,5-di-n-propoxyphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (338 mg, 0.63 mmol) in dichloromethane (3 mL) and pyridine (1.3 mL). The reaction mixture was stirred at room temperature for 2 h, and worked-up as usual to give a syrup, Rf 0.52 (hexane-ethyl acetate; 1:2 v/v). This material was used directly in the next experiment without further purification.

Provenance & Evidence