HCID 10722812, compound → HCID 131717384, compound

HRID 1196732Notes

Reaction equation

HRID 1196732 reaction equation
[NH:1]1[C:45](=[O:46])[C@H:40]([CH2:41][CH:42]([CH3:44])[CH3:43])[NH:39][C:37](=[O:38])[C@@H:33]([CH:34]([CH3:36])[CH3:35])[NH:32][C:30](=[O:31])[C@H:24]([CH2:25][CH2:26][CH2:27][CH2:28][NH2:29])[NH:23][C:21](=[O:22])[C@@H:16]([CH2:17][C:18](=[O:20])[OH:19])[NH:15][C:13](=[O:14])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[C:47](OC=O)(=[O:52])C(C)(C)C>CN(C=O)C>[NH:1]1[C:45](=[O:46])[C@H:40]([CH2:41][CH:42]([CH3:44])[CH3:43])[NH:39][C:37](=[O:38])[C@@H:33]([CH:34]([CH3:36])[CH3:35])[NH:32][C:30](=[O:31])[C@H:24]([CH2:25][CH2:26][CH2:27][CH2:28][NH:29][CH:47]=[O:52])[NH:23][C:21](=[O:22])[C@@H:16]([CH2:17][C:18](=[O:19])[OH:20])[NH:15][C:13](=[O:14])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

Participants

4

Reactant 2

HCID 10722812HCID 10722812, compoundHCID 11804789HCID 11804789, compound

Product 1

HCID 131717384HCID 131717384, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of cyclo(-DTrp-DAsp-Lys-DVal-Leu-) (10.5 mg) which was prepared in Example 4, and formic pivalic anhydride(10 ml) in DMF(0. 5ml) was added TEA(10 μl). The reaction mixture was stirred at room temperature for 1 h and concentrated in vacuo. The residue was triturated with water (2 ml) to give the title compound(7.8 mg) as an off-white powder.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe residue was triturated with water (2 ml)

Sources & evidence

ORD record
ord-68fbb2a84427457ea8a6fe6a4676d38b
Source dataset
uspto-grants-1992_05
Patent number
US05114918

Reaction notes

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