Hydrogen Peroxide → HCID 131717385, compound

HRID 1196733Notes

Reaction equation

HRID 1196733 reaction equation
[NH:1]1[C:46](=[O:47])[C@H:41]([CH2:42][CH:43]([CH3:45])[CH3:44])[NH:40][C:38](=[O:39])[C@@H:34]([CH:35]([CH3:37])[CH3:36])[NH:33][C:31](=[O:32])[C@H:26]([CH2:27][CH2:28][S:29][CH3:30])[NH:25][C:23](=[O:24])[C@@H:18]([CH2:19][C:20](=[O:22])[OH:21])[NH:17][C:15](=[O:16])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH:13]=[O:14])[CH:5]=1.[OH:48]O>C(O)(=O)C>[NH:1]1[C:46](=[O:47])[C@H:41]([CH2:42][CH:43]([CH3:45])[CH3:44])[NH:40][C:38](=[O:39])[C@@H:34]([CH:35]([CH3:37])[CH3:36])[NH:33][C:31](=[O:32])[C@H:26]([CH2:27][CH2:28][S:29]([CH3:30])=[O:48])[NH:25][C:23](=[O:24])[C@@H:18]([CH2:19][C:20](=[O:21])[OH:22])[NH:17][C:15](=[O:16])[C@H:2]1[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH:13]=[O:14])[CH:5]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 131717386HCID 131717386, compound

Product 1

HCID 131717385HCID 131717385, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of cyclo(-DTrp(CHO)-DAsp-Met-DVal-Leu-) (12.9 mg) which was prepared in Example 55 in acetic acid(2.0 ml) was added 35% H2O2 (5 μl). The reaction mixture was stirred at room temperature for 3 h and concentrated under reduced pressure till the volume of the mixture was reduced to ca. 1 ml. The residue was triturated with water(3 ml) to give the title compound (7.6 mg) as a pale yellow powder.

Workup

  1. concentrationconcentrated under reduced pressure till the volume of the mixture
  2. customThe residue was triturated with water(3 ml)

Sources & evidence

ORD record
ord-e3d51e2fc5c741df9ffb41aed74e7156
Source dataset
uspto-grants-1992_05
Patent number
US05114918

Reaction notes

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