p-Toluenesulfonic acid → HCID 19896184, compound

HRID 1196746Notes

Reaction equation

HRID 1196746 reaction equation
O.[O:2]=[CH:3][C:4]([Cl:7])([Cl:6])[Cl:5].[CH2:8]([OH:13])[CH2:9][CH:10]([CH3:12])[CH3:11].[CH3:14][C:15]1[CH:20]=CC(S(O)(=O)=O)=[CH:17][CH:16]=1>C1C=CC=CC=1>[CH2:17]([O:2][CH:3]([O:13][CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])[C:4]([Cl:7])([Cl:6])[Cl:5])[CH2:16][CH:15]([CH3:20])[CH3:14]

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 31260Isoamyl AlcoholHCID 205283762,2,2-Trichloroacetaldehyde hydrate

Product 1

HCID 19896184HCID 19896184, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 5 g of chloral-hydrate, 10 g of isoamyl-alcohol, 0.1 g of 4-methyl-benzene-sulphonic acid and 50 ml of benzene is kept at reflux temperature and the formed water is separated by means of a Dean-Stark apparatus. After a reaction time of 9 hours the benzene is washed with a sodium-hydrogen-carbonate solution and water, dried on magnesium sulfate, then vacuum distilled.

Workup

  1. temperatureat reflux temperature
  2. customthe formed water is separated by means of a Dean-Stark apparatus
  3. washAfter a reaction time of 9 hours the benzene is washed with a sodium-hydrogen-carbonate solution and water
  4. customdried on magnesium sulfate
  5. distillationvacuum distilled

Sources & evidence

ORD record
ord-85812d933c214b1b86bac748c720cff6
Source dataset
uspto-grants-1992_05
Patent number
US05116402

Reaction notes

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