反应详情

4.7 g. (20 mmole) of the above compound were mixed in 50 ml. pyridine, while cooling with ice, with 3.7 g. (22 mmole) 4-methoxybenzoyl chloride. After 2 hours at 25° C., the reaction mixture was poured on to ice, acidified with 2N hydrochloric acid, extracted with methylene chloride, dried and evaporated to give 6.9 g. (93% of theory) 4,4-dimethyl-6-(4-methoxybenzoylamino)-7-nitro- 1,2,3,4-tetrahydroquinolin-2-one; m.p. 288°-290° C.

1. additionthe reaction mixture was poured on to ice
2. extractionextracted with methylene chloride
3. customdried
4. customevaporated
5. customto give 6.9 g