Hydrochloric Acid → HCID 178426917, compound

HRID 1196893Notes

Reaction equation

HRID 1196893 reaction equation
[CH3:1][C:2]1([CH3:15])[C:11]2[C:6](=[CH:7][C:8]([NH2:13])=[C:9]([NH2:12])[CH:10]=2)[NH:5][C:4](=[O:14])[CH2:3]1.Cl.[C:17](Cl)(Cl)=[O:18]>>[CH3:1][C:2]1([CH3:15])[C:11]2[CH:10]=[C:9]3[NH:12][C:17]([OH:18])=[N:13][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:14])[CH2:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6371PhosgeneHCID 19896766HCID 19896766, compound

Product 1

HCID 178426917HCID 178426917, compound

Procedure

2 g. (9.7 mmole) 4,4-dimethyl-6,7-diamino-1,2,3,4-tetrahydroquinolin-2-one (see Example 13 a)) were dissolved in 50 ml. 2N hydrochloric acid and phosgene passed in for 1 hour. The evaporation residue was recrystallized from methanol to give 1.6 g. (72% of theory) of the title compound; m.p. >300° C.

Workup

  1. dissolutionwere dissolved in 50 ml
  2. custompassed in for 1 hour
  3. customThe evaporation residue was recrystallized from methanol
  4. customto give 1.6 g

Sources & evidence

ORD record
ord-b724b4a95a0741659d3120024430db41
Source dataset
uspto-grants-1992_05
Patent number
US05116843

Reaction notes

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