HCID 19896765, compound → HCID 19896763, compound

HRID 1196900Notes

Reaction equation

HRID 1196900 reaction equation
[CH3:1][C:2]1([CH3:31])[C:11]2[CH:10]=[C:9]3[NH:12][C:13]([C:15]4[CH:20]=[CH:19][C:18]([N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[CH:17][C:16]=4[O:26][CH2:27][CH:28]=[CH2:29])=[N:14][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:30])[CH2:3]1>C(O)C.[Pd]>[CH3:31][C:2]1([CH3:1])[C:11]2[CH:10]=[C:9]3[NH:12][C:13]([C:15]4[CH:20]=[CH:19][C:18]([N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])=[CH:17][C:16]=4[O:26][CH2:27][CH2:28][CH3:29])=[N:14][C:8]3=[CH:7][C:6]=2[NH:5][C:4](=[O:30])[CH2:3]1

Participants

4

Reactant 1

HCID 19896765HCID 19896765, compound

Product 1

HCID 19896763HCID 19896763, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2 g. 8,8-Dimethyl-2-(4-diethylamino-2-allyloxyphenyl)-5,6,7,8-tetrahydro-1H-imidazo[4,5-g]quinolin-6one were hydrogenated in ethanol in the presence of palladium/charcoal. After completion of the take up of hydrogen, the catalyst was filtered off, the filtration was evaporated and the residue recrystallized from isopropanol to give 1.8 g. of the title compound; m.p. 147°-148° C.

Workup

  1. filtrationAfter completion of the take up of hydrogen, the catalyst was filtered off
  2. filtrationthe filtration
  3. customwas evaporated
  4. customthe residue recrystallized from isopropanol
  5. customto give 1.8 g

Sources & evidence

ORD record
ord-728abd536ba442f2b4062b2e40eac997
Source dataset
uspto-grants-1992_05
Patent number
US05116843

Reaction notes

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