HCID 19896766, compound → HCID 19896776, compound

HRID 1196901Notes

Reaction equation

HRID 1196901 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=O)=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][C:14]1([CH3:27])[C:23]2[C:18](=[CH:19][C:20]([NH2:25])=[C:21]([NH2:24])[CH:22]=2)[NH:17][C:16](=[O:26])[CH2:15]1>>[CH3:13][C:14]1([CH3:27])[C:23]2[CH:22]=[C:21]3[NH:24][C:6]([C:5]4[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][C:4]=4[O:11][CH3:12])=[N:25][C:20]3=[CH:19][C:18]=2[NH:17][C:16](=[O:26])[CH2:15]1

Participants

3

Reactant 2

HCID 19896766HCID 19896766, compoundHCID 221424504-Chloro-2-methoxybenzoyl chloride

Product 1

HCID 19896776HCID 19896776, compoundYield 58%

Procedure

In a manner analogous to that described in EXAMPLE 2, from 4-chloro-2-methoxybenzoyl chloride and 4,4-dimethyl-6,7-diamino-1,2,3,4-tetrahydroquinolin-2-one (see Example 13 a)), after column chromatography, there was obtained a yield of 58% of theory of the title compound; m.p. 300°-303° C.

Sources & evidence

ORD record
ord-0e4f8c8044364a3b9a11a628fa4ef650
Source dataset
uspto-grants-1992_05
Patent number
US05116843

Reaction notes

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